Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010704" target="_blank" >RIV/00216224:14110/04:00010704 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)

Original language description

The aim of the study was to investigate possible associations of IL-6 gene polymorphisms (596 A/G and 174 C/G) with cutaneous T-cell lymphoma (CTCL). In the case-control study, genotype distributions and allelic frequencies in two promoter IL-6 gene polymorphisms in the group of 63 Czech patients with CTCL were compared to those of 105 control non-CTCL subjects matched for aged and sex. The IL-6 gene polymorphisms were determined by PCR with following restriction analysis. A significant difference of 596 A/G IL-6 genotype distribution was found between the CTCL patients and the controls (P=0.002) with almost threefold odds ratio for the heterozygote (AG) genotype in CTCL patients (OR=2.64, P=0.002). No significant differences in genotype distribution and/or allelic frequency of functional -174C/G IL-6 gene polymorphism were observed. The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with CTCL (OR=2.24, 95% confidence interval 1.17-4.28, P=0.01). Thus, the

Czech name

Heterozygot AG polymorfismu -596 A/G v genu pro IL-6 je marker pro kožní T-lymfom (CTCL)

Czech description

Prokázali jsme signifikantní rozdíl v distribuci genotypu -596 A/G IL-6 mezi pacienty s CTCL a kontrolami (P=0,002) s téměř trojnásobným odds ratio pro heterozygotní genotyp AG u pacientů s CTCL orpoti kontrolám (OR=2,64, P=0,002).

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Immunology

ISSN

1521-6616

e-ISSN

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Volume of the periodical

113

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

256-260

UT code for WoS article

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EID of the result in the Scopus database

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