Glutamate and behavioural sensitization: review of the experimental studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010762" target="_blank" >RIV/00216224:14110/04:00010762 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Glutamate and behavioural sensitization: review of the experimental studies

Original language description

Repeated drug administration leading to a progressively enhanced response persisting even after long periods of withdrawal, a phenomenon termed sensitization, is suggested to be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. Thus, sensitization is known to be induced by agents acting directly or indirectly on the dopaminergic VTA-accumbens projection and development of sensitization is reported to require transient increase in glutamatergic neurons from the prefrontal cortex to the ventral tegmental area (VTA) leading to activation of the mentioned dopaminergic pathway (Everitt and Wolf, 2002). This suggestion is supported by studies in which the development of behavioural sensitization to cocaine, amphetamine, methamphetamine and morphine as one of forms of neuronal plasticity was prevented by noncompetitive (dizocilpine, memantine) and competitive (CGS 1975) glutamate NMDA receptor antagonists (e.g. Karler et

Czech name

Glutamát a behaviorální sensitizace: přehled experimentálních studií

Czech description

Podán přehled v literatuře dostupných experimentálních studií o roli glutamátergního transmiterového systému v procesech behaviorální sensitizace k látkám vyvolávajícícm závislost.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

Suppl.4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

1

Pages from-to

47-47

UT code for WoS article

—

EID of the result in the Scopus database

—