Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010864" target="_blank" >RIV/00216224:14110/04:00010864 - isvavai.cz</a>
Alternative codes found
RIV/61388998:_____/04:00103602
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells
Original language description
A mathematical model of the interaction of propafenone with cardiac sodium channels is based on experimental data that demonstrate use-dependent effect of the drug. The model of CLANCY and RUDY (Circulation, 2002; 105: 1208-1213) is applied to describe Na-channel in absence of the drug. The values of rate constants of the drug-receptor reaction are fitted to experimental data by iterative computer simulations using a genetic algorithm. The model suggests that drug molecules have an access to the bindingsites predominantly in the inactivated states and that accumulation of blocked channels in the slow inactivated state is responsible for the observed use- dependent effects. The results of quantitative modelling predict that propafenone (0.2 mmol/l) effectively suppresses premature excitations leaving the regular action potentials nearly unaffected.
Czech name
Výpočtové modelování interakce propafenonu se sodíkovými kanály srdečních buněk
Czech description
Práce popisuje sestavení matematického modelu interakce propafenonu se sodíkovými kanály srdečních buněk. Výsledky výpočtového modelování vlivu propafenonu na elektrickou aktivitu buněk ukázaly, že propafenon (0.2 mmol/l) účinně potlačuje předčasné excitace přičemž pravidelné excitace ponechává téměř neovlivněny.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical & Biological Engineering & Computing
ISSN
0140-0118
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
151-157
UT code for WoS article
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EID of the result in the Scopus database
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