Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00005060" target="_blank" >RIV/00216224:14110/01:00005060 - isvavai.cz</a>
Alternative codes found
RIV/61388998:_____/01:51010109
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells.
Original language description
A mathematical model of the interaction of propafenone with sodium channels is based on experimental data that demonstrate use dependent effect of the drug. Transitions among channel states are described by a kinetic diagram and a corre-sponding set of differential equations. The values of rate constants of the drug-receptor reaction are fitted to experimental data by repeated computer simulations using a genetic algorithm. The model suggests the following interpretation of the obtained experimental results: 1) The affinity of the drug to its binding site is high in the open and inactivated states while it is low in the resting state. 2) The biphasic development of the block during depolarization is consistent with a high association rate constant in the open state and a lower one in the inactivated state. 3) The observed double exponential time course of recovery of INa at resting voltage after depolarizing pulse may result from concurrent drug release from inactivated and non-inactiv
Czech name
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Czech description
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Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the International Federation for Medical and Biologocal Engineering
ISBN
953-184-024-5
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
1028
Publisher name
Faculty of Electrical Engineering, Zagreb
Place of publication
Pula (Croatia)
Event location
Pula (Croatia)
Event date
Jan 1, 2001
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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