Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00011945" target="_blank" >RIV/00216224:14110/04:00011945 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study
Original language description
We explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea pig ventricular cardiomyocytes by means of mathematical models. The simulations revealed significant changes of tubular calcium and potassium concentrations at different stimulation rates. In the rat model, the transient depletion of tubular Ca2+ increased from 7.3 % to 14 % (related to external level) and the transient accumulation of tubular K+ decreased from 4.3 % to 3 % with increase of stimulation rate from 1 Hz to 5 Hz. The guinea pig model, on the contrary, exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency-range.
Czech name
Iontově-koncentrační změny v tubulárním systému srdečních buněk morčete a potkana: simulační studie
Czech description
Práce prezentuje výsledky vyšetření velikosti iontově-koncentračních změn v transverzálně-axiálním tubulárním systému srdečních buněk laboratorního potkana a morčete provedené na matematických modelech.

Project
<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Abstract Book of the 4th International Symposium on Membrane Channels, Transporters and Receptors
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
56
Publisher name
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Place of publication
Smolenice
Event location
Smolenice
Event date
Jan 1, 2004
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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