Ionic concentration changes in the tubular system of rat ventricular cardiac cell model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010869" target="_blank" >RIV/00216224:14110/04:00010869 - isvavai.cz</a>
Alternative codes found
RIV/61388998:_____/04:00103603
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Ionic concentration changes in the tubular system of rat ventricular cardiac cell model
Original language description
We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and thedistribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload.
Czech name
Iontově-koncetrační změny v tubulárním systému modelu komorové buňky potkana
Czech description
Práce prezentuje sestavení matematického modelu komorové buňky laboratorního potkana se zahrnutým popisem funkce transverzálně - axiálního tubulárního systému a představuje výsledky simulací odhalující velikost iontově-koncentračních změn uvnitř tubulárního systému potkana.
Classification
Type
D - Article in proceedings
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Engineering Mechanics 2004
ISBN
80-85918-88-9
ISSN
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e-ISSN
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Number of pages
9
Pages from-to
1-9
Publisher name
Institute of Thermomechanics, Academy of Sciences of the Czech Republic
Place of publication
Svratka
Event location
Svratka
Event date
May 10, 2004
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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