The functional role of cardiac T-tubules in a model of rat ventricular myocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00015542" target="_blank" >RIV/00216224:14110/06:00015542 - isvavai.cz</a>
Alternative codes found
RIV/61388998:_____/06:00041960
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The functional role of cardiac T-tubules in a model of rat ventricular myocytes
Original language description
The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation andtransient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.
Czech name
Funkční role srdečních T-tubulů v modelu komorové buňky krysy
Czech description
Práce popisuje výsledky vyšetření fyziologických důsledků iontově koncentračních změn v transverzálně-axiálním tubulárním systému u srdeční komorové buňky potkana. Vyšetření je provedeno na představeném matematickém modelu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Philosophical Transactions of the Royal Society
ISSN
1364-503X
e-ISSN
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Volume of the periodical
364
Issue of the periodical within the volume
1842
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
1187-1206
UT code for WoS article
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EID of the result in the Scopus database
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