Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00011947" target="_blank" >RIV/00216224:14110/04:00011947 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes

Original language description

The majority of trans-sarcolemmal Ca2+ flux occurs across the t-tubule membrane, which therefore plays a key role in cardiac excitation-contraction coupling; however Ca2+ within the t-tubules does not equilibrate instantaneously with the bulk extracellular solution. Thus, during activity, changes in [Ca2+] may occur within the t-tubule lumen, which would, in turn, alter trans-sarcolemmal Ca2+ flux. To test this hypothesis, we used a computer model of rat ventricular myocyte including a t-tubular system.The action potentials in the two membranes were not significantly different, reflecting the electrical coupling of the two compartments. However, [Ca2+] within the t-tubule lumen decreased on each stimulus, and decreased cumulatively, until reaching a new dynamic steady state, with increasing stimulation rate. These data suggest that activity-dependent depletion of Ca2+ within the t-tubule lumen, adjacent to the trans-sarcolemmal Ca2+ flux pathways, decreases the Ca load, and hence lowe

Czech name

Změny [Ca2+] uvnitř t-tubulů mohou měnit inotropní stav srdečních ventrikulárních buněk potkana

Czech description

Práce prezentuje výsledky simulací na modelu srdeční komorové buňky potkana ukazující vliv koncentračních změn tubulárních iontů Ca2+ (během buněčné aktivity) na intracelulární vápníkovou rovnováhu a inotropní stav komorových buněk.

Type

D - Article in proceedings

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings of The Physiological Society

ISBN

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ISSN

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e-ISSN

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Number of pages

1

Pages from-to

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Publisher name

University of Oxford

Place of publication

Oxford

Event location

Oxford

Event date

Nov 1, 2004

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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