Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00062449" target="_blank" >RIV/00216224:14110/12:00062449 - isvavai.cz</a>
Alternative codes found
RIV/61388998:_____/12:00376860
Result on the web
<a href="http://dx.doi.org/10.1007/s00249-012-0804-x" target="_blank" >http://dx.doi.org/10.1007/s00249-012-0804-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00249-012-0804-x" target="_blank" >10.1007/s00249-012-0804-x</a>
Alternative languages
Result language
angličtina
Original language name
Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte
Original language description
The t-tubules of mammalian ventricular myocytes are invaginations of the surface membrane that form a complex network within the cell, with restricted diffusion to the bulk extracellular space. The trans-sarcolemmal flux of many ions, including Ca2+, occurs predominantly across the t-tubule membrane and thus into and out of this restricted diffusion space. It appears possible, therefore, that ion concentration changes may occur in the t-tubule lumen, which would alter ion flux across the t-tubule membrane. We have used a computer model of the ventricular myocyte, incorporating a t-tubule compartment and experimentally determined values for diffusion between the t-tubule lumen and bulk extracellular space, and ion fluxes across the t-tubule membrane, toinvestigate this possibility. The results show that influx and efflux of different ion species across the t-tubule membrane are similar, but not equal.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Biophysics Journal With Biophysics Letters
ISSN
0175-7571
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
491-503
UT code for WoS article
000304445400001
EID of the result in the Scopus database
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