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Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014822" target="_blank" >RIV/00216224:14110/05:00014822 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte

  • Original language description

    The contribution of surface and t-tubular membranes to cation homeostasis was evaluated in a model of the guinea-pig ventricular myocyte with a single-compartment representation of the transverse-axial tubular system (TATS) matching detailed ultrastructural data (1), with 53% of the cell membrane in the TATS, and ionic diffusion data (2). The TATS fraction of ion transfer mechanisms was set to 0.53 (uniform distribution) except for INa and ICaL (0.64), IK1 (0.8), Na/Ca exchange (0.7) and Ca-pump (0.2).At steady-state during 4 Hz stimulation in current-clamp, 67% of Ca2+ influx occurred across the TATS membrane, while 53% of Ca2+ extrusion occurred across the surface membrane. Thus the TATS membrane mediates net Ca2+ influx, while the surface membranemediates net Ca2+ efflux. Transient partial depletion of Ca2+ within the TATS lumen during the action potential was compensated by diffusion from the bulk external solution. Thus within a single beat there was net intracellular Ca2+ flux

  • Czech name

    Cirkulace iontů mezi tubulární a periferní membránou v modelu srdeční komorové buňky morčete

  • Czech description

    Práce prezentuje výsledky kvantitativního vyšetření role periferní a tubulární membrány v udržení intracelulární iontové rovnovahy u modelu srdeční komorové buňky morčete.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Molecular and Cellular Cardiology

  • ISSN

    0022-2828

  • e-ISSN

  • Volume of the periodical

    39

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    1

  • Pages from-to

    174-174

  • UT code for WoS article

  • EID of the result in the Scopus database