Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014822" target="_blank" >RIV/00216224:14110/05:00014822 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte
Original language description
The contribution of surface and t-tubular membranes to cation homeostasis was evaluated in a model of the guinea-pig ventricular myocyte with a single-compartment representation of the transverse-axial tubular system (TATS) matching detailed ultrastructural data (1), with 53% of the cell membrane in the TATS, and ionic diffusion data (2). The TATS fraction of ion transfer mechanisms was set to 0.53 (uniform distribution) except for INa and ICaL (0.64), IK1 (0.8), Na/Ca exchange (0.7) and Ca-pump (0.2).At steady-state during 4 Hz stimulation in current-clamp, 67% of Ca2+ influx occurred across the TATS membrane, while 53% of Ca2+ extrusion occurred across the surface membrane. Thus the TATS membrane mediates net Ca2+ influx, while the surface membranemediates net Ca2+ efflux. Transient partial depletion of Ca2+ within the TATS lumen during the action potential was compensated by diffusion from the bulk external solution. Thus within a single beat there was net intracellular Ca2+ flux
Czech name
Cirkulace iontů mezi tubulární a periferní membránou v modelu srdeční komorové buňky morčete
Czech description
Práce prezentuje výsledky kvantitativního vyšetření role periferní a tubulární membrány v udržení intracelulární iontové rovnovahy u modelu srdeční komorové buňky morčete.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular and Cellular Cardiology
ISSN
0022-2828
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
1
Pages from-to
174-174
UT code for WoS article
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EID of the result in the Scopus database
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