Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00013081" target="_blank" >RIV/00216224:14110/05:00013081 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes
Original language description
The main determinants of rate-dependent of action potential duration in rat ventricular myocytes are variations of the L-type calcium current ICa-L (gradual increase caused by modulatory effect of the Ca2+ transient) and the transient outward current Ito(decrease due to cumulative inactivation). These contemporary variations of ICa-L and Ito supported each other in the rate-dependent modulation of action potential prolongation. Under our experimental conditions, participation of other currents was negligible.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA305%2F04%2F1385" target="_blank" >GA305/04/1385: Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů