IMMUNOHISTOCHEMICAL STAINING FOR pCREB IN THE DORSAL ROOT GANGLION NEURONS OF VARIOUS EXPERIMENTAL MODELS OF NEUROPATHIC PAIN

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014433" target="_blank" >RIV/00216224:14110/05:00014433 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

IMMUNOHISTOCHEMICAL STAINING FOR pCREB IN THE DORSAL ROOT GANGLION NEURONS OF VARIOUS EXPERIMENTAL MODELS OF NEUROPATHIC PAIN

Original language description

Immunoreactivity for pCREB was localized surprisingly in the nucleoli of the DRG neurons of both naive and operated rats. In comparison to DRG neurons from naive rats, significant increased immunostaining for pCREB was found in the neurons of both ipsilateral and contralateral DRG following various types of nerve injuries. The present results demonstrated that increased phosphorylation of CREB induced by nerve injury may be involved in the development neuropathic pain. Similar bilateral exhibition of increased pCREB immunostaining suggested a retrograde neuroinflammation signalling of the neuropathic pain development.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů