Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00021928" target="_blank" >RIV/00216224:14110/05:00021928 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes
Original language description
Ajmaline decreased the upstroke velocity of action potential and its amplitude, very likely by inhibition of sodium current INa. The observed prolongation of action potential was probably related to the inhibition of transient outward potassium current Ito, the main repolarizing current in rat. This effect predominates over the opposite effect of the inhibition of calcium current ICaL, partly because of lower IC50.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů