A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00016675" target="_blank" >RIV/00216224:14110/06:00016675 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF
Original language description
MSF is a truncated (70kDa) isoform of fibronecting displaying number of potent biactivities mediated by IGD-amino acid motif. Two MSF isoforms, differing in terms of 15 amino acid deletion in a module II-1, have been identified. While IGD-mediated bioactivities od both isoforms are identical, deleted isoform (MSF-aa) is not inhibited by recently characterised inhibitor produced by normal keratinocytes. Furthermore, various cancer cell lines produce MSF activity which is not inhibited or partly inhibitedby MSF inhibitor.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LZ1K03019" target="_blank" >LZ1K03019: MU_Kaňková</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů