Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017183" target="_blank" >RIV/00216224:14110/06:00017183 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure
Original language description
Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.
Czech name
Sérová matrix metalloproteinasa (MMP-2) a její tkáňový inhibitor (TIMP-1) ve vztahu k pro- a anti-fibrotickým faktorům u pacientů se srdečním selháním
Czech description
Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.
Classification
Type
D - Article in proceedings
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings from XX. Biochemický zjazd
ISBN
80-969532-6-5
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
358
Publisher name
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Place of publication
Bratislava
Event location
Piešťany, Slovak Republic
Event date
Jan 1, 2006
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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