ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017421" target="_blank" >RIV/00216224:14110/06:00017421 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES

Original language description

The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GG genotype (OR=2.84, 95%CI 1.14-7.07, p=0.02). There is a significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02-3.14, p=0.03). Furthermore, evaluations of preeclamptic patients data revealed a significant association of gen

Czech name

Asociace genetického polymorfismu -2548 G/A v genu pro leptin s gestačním diabetem

Czech description

Získaná data naznačují, ze variabilita v genu pro leptin, konkrétně definovaný polymorfismus -2548 G/A se může uplatnit jako etiopatogenetický faktor při vzniku gestačního diabetu nebo obecně při poruchách fetálního růstu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genes and Nutrition

ISSN

1555-8932

e-ISSN

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Volume of the periodical

2/2006

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

117-124

UT code for WoS article

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EID of the result in the Scopus database

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