The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081410" target="_blank" >RIV/00023001:_____/21:00081410 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10431115 RIV/00216224:14110/21:00120128 RIV/00216208:11310/21:10431115
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s11033-021-06581-w.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s11033-021-06581-w.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11033-021-06581-w" target="_blank" >10.1007/s11033-021-06581-w</a>
Alternative languages
Result language
angličtina
Original language name
The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics
Original language description
BACKGROUND: Common polymorphisms within the apolipoprotein E (APOE) gene are suggested to be associated with the development of type 2 diabetes mellitus (T2DM), but the potential association with T2DM complications (nephropathy, neuropathy and retinopathy) remains unclear. We perform the case-control study to analyse the association between the APOE polymorphism and risk of T2DM and to analysed the potential relationship between the APOE and T2DM complications. METHODS AND RESULTS: APOE variants (rs429358 and rs7412) were genotyped by TaqMan assay in T2DM patients (N = 1274; N = 829 with complications including retinopathy, neuropathy and nephropathy status) and with PCR-RFLP in healthy nondiabetic controls (N = 2055). The comparison of subjects with genotypes associated with low plasma cholesterol (APOE2/E2 and APOE2/E3 carriers vs. others) did not show an association with T2DM (OR [95% CI] = 0.88 [0.71-1.08). The differences remained insignificant after adjusting for diabetes duration, sex and BMI. Carriers of at least one APOE4 allele (rs429358) are protected against T2DM related retinopathy (OR [95% CI] = 0.65 [0.42-0.99]. Protection against retinopathy is driven mostly by females (OR [95% CI] = 0.50 [0.25-0.99]); and remains significant (P = 0.044) after adjustment for diabetes duration and BMI. CONCLUSION: Common APOE polymorphism was not associated with T2DM in the Czech population. Yet, APOE4 allele revealed an association with retinopathy. In particular, female T2DM patients with at least one APOE4 allele exhibit lower prevalence of retinopathy in our study subjects.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV18-01-00046" target="_blank" >NV18-01-00046: Genetic score in prediction of diabetes and its complications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular biology reports
ISSN
0301-4851
e-ISSN
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Volume of the periodical
48
Issue of the periodical within the volume
8
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
5873-5879
UT code for WoS article
000679622300004
EID of the result in the Scopus database
2-s2.0-85111555673