Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017758" target="_blank" >RIV/00216224:14110/06:00017758 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy
Original language description
The study tested an antidepressant effect of cannabidiol (CBD) in olfactory bulbectomized (OB) mice, a well-established animal model of depression resembling behavioural, immune and endocrine changes. CBD did not show antidepressant behavioural properties in this animal model. This can discussed in relation to our previous results in social defeat mouse model, where CBD appeared to elicit anxiolytic activity. Reversal of the suppressed leukocyte phagocytosis in the OB mice by CBD correlates with the stimulatory effect of cannabinoids reffered in the literature.
Czech name
Behaviorální a imunitní účinky kanabidiolu v myším modelu bilaterální olfaktorické bulbektomie
Czech description
Sledovány byly behaviorální a imunitní účinky kanabidiolu v myším modelu deprese - bilaterální olfaktorické bulbektomie. Behaviorální antidepresivní účinky kanabidiolu nebyly jednoznačně prokázány. Kanabidiol normalizoval potlačenou leukocytární fagocytózu v použitém zvířecím modelu deprese.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The International Journal of Neuropsychopharmacology
ISSN
1461-1457
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
1
Pages from-to
778
UT code for WoS article
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EID of the result in the Scopus database
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