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Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017758" target="_blank" >RIV/00216224:14110/06:00017758 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy

  • Original language description

    The study tested an antidepressant effect of cannabidiol (CBD) in olfactory bulbectomized (OB) mice, a well-established animal model of depression resembling behavioural, immune and endocrine changes. CBD did not show antidepressant behavioural properties in this animal model. This can discussed in relation to our previous results in social defeat mouse model, where CBD appeared to elicit anxiolytic activity. Reversal of the suppressed leukocyte phagocytosis in the OB mice by CBD correlates with the stimulatory effect of cannabinoids reffered in the literature.

  • Czech name

    Behaviorální a imunitní účinky kanabidiolu v myším modelu bilaterální olfaktorické bulbektomie

  • Czech description

    Sledovány byly behaviorální a imunitní účinky kanabidiolu v myším modelu deprese - bilaterální olfaktorické bulbektomie. Behaviorální antidepresivní účinky kanabidiolu nebyly jednoznačně prokázány. Kanabidiol normalizoval potlačenou leukocytární fagocytózu v použitém zvířecím modelu deprese.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    The International Journal of Neuropsychopharmacology

  • ISSN

    1461-1457

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    1

  • Pages from-to

    778

  • UT code for WoS article

  • EID of the result in the Scopus database