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The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017778" target="_blank" >RIV/00216224:14110/06:00017778 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver.

  • Original language description

    Interindividual variability of activity of oxidative and conjugating enzymes, especially the system of cytochrome P450, can be based on many different factors i.e. gender, age, genetic factors or interactions between simultaneously applied drugs. Such avariability may result in a different pharmacoterapeutical effectivity, adverse effects or toxicity of apllied drug. A suitable model for investigations on the activity of hepatic CYPs 450 and biotransformation processes is represented by the isolated perfused liver. As we expected, the activity of CYP subfamilies differed due to gender. CYP 2D2 activity in rat females was significantly higher than in males (Fig. 1). Also the final concentration of a marker metabolite (dextrorphan) in females was higheronly in CYP 2D2. The elevation was 5,7% in the 30th min, 33% in the 60th min and 34% in the 120th min. In contrast activity in CYP 3A subfamily in females was lower than in males. Next two isoforms of CYP450, used as markers were tolbuta

  • Czech name

    Vliv pohlaví na metabolickou aktivitu enzymatickeho systemu cytochromu P450 na modele izolovaných prerfundovaných jater.

  • Czech description

    Preklinické experimenty sú založené na využívaní zvieracích modelov k predikcii vplyvu látky na ľudský oragnizmus. Cytochróm P-450 (CYP-450) hraje kľúčovú úlohu v biotransformačných procesoch veľkého množstva xenobiotík. Je to enzymatický systém podieľajúci sa na tvorbe cholesterolu a žlčových kyselín, steroidov, prostacyklínov a tromboxanu A2 (Nelson a kol., 1996). Interindividuálna variabilita aktivity oxidatívnych a konjugačných enzýmov, hlavne CYP-450, môže byť zapríčinená roznymi faktormi ako napr.druh, pohlavie, vek, genetický základ jedinca, alebo interakcie medzi súčastne podávanými liečivami, dosledkom čoho može byť rozna farmakoterapeutická účinnosť liečiva , ako aj výskyt a intenzita nežiadúcich až toxických účinkov. Výsledky ukázali, že aktivita CYP2D2 u samíc je signifikantne vyššia než u samcov (v 30. min. zvýšená o 5.7%, v 60. min. o 33% a v 120. min. o 34%). Aktivita CYP3A bola u samíc nižšia než u samcov. Ako u jedinej nami sledovanej izoformy bola výsledná koncentrác

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Homeostasis in Health and Diseases

  • ISSN

    0960-7560

  • e-ISSN

  • Volume of the periodical

    44

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    IT - ITALY

  • Number of pages

    3

  • Pages from-to

    128-130

  • UT code for WoS article

  • EID of the result in the Scopus database