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Can we detect the development of baroreflex sensitivity in humans between 11 and 20 years of age?

Result description

The aim of the study was to determine changes of baroreflex sensitivity (BRS/BRSf) in humans between 11 and 20 years of age. Beat-by-beat values of inter-beat intervals (IBI) or heart rate, and systolic and diastolic blood pressures were measured for 5 min in 415 healthy subjects. BRS did not correlate with age, but BRSf significantly decreased (p<0.001). BRS correlated with mean IBI (p<0.001), but BRSf was IBI-independent. Results of multiregression equations were: BRS=1.37-0.56*age+0.02*IBI (p<0.001 for BRS vs. age and for BRS vs. IBI); BRSf=34.74?0.97*age-0.001*IBI (p<0.001 only for BRS vs. age). The limits of BRS: 5th percentile - 3.9 ms/mmHg; 50th - 9.1; 95th - 18.7, and limits for BRSf: 5th percentile - 8.5 mHz/mmHg; 50th - 16.4; 95th- 33.6. Conclusion: IBI-dependent BRS was unchanged in the particular age groups, but the standardization of BRS on IBI was decreased with age. BRSf was IBI-independent and better reflected the development of the baroreflex sensitivity.

Keywords

baroreflex sensitivityspectral analysisageadolescentschildren

The result's identifiers

Alternative languages

  • Result language

    angličtina

  • Original language name

    Can we detect the development of baroreflex sensitivity in humans between 11 and 20 years of age?

  • Original language description

    The aim of the study was to determine changes of baroreflex sensitivity (BRS/BRSf) in humans between 11 and 20 years of age. Beat-by-beat values of inter-beat intervals (IBI) or heart rate, and systolic and diastolic blood pressures were measured for 5 min in 415 healthy subjects. BRS did not correlate with age, but BRSf significantly decreased (p<0.001). BRS correlated with mean IBI (p<0.001), but BRSf was IBI-independent. Results of multiregression equations were: BRS=1.37-0.56*age+0.02*IBI (p<0.001 for BRS vs. age and for BRS vs. IBI); BRSf=34.74?0.97*age-0.001*IBI (p<0.001 only for BRS vs. age). The limits of BRS: 5th percentile - 3.9 ms/mmHg; 50th - 9.1; 95th - 18.7, and limits for BRSf: 5th percentile - 8.5 mHz/mmHg; 50th - 16.4; 95th- 33.6. Conclusion: IBI-dependent BRS was unchanged in the particular age groups, but the standardization of BRS on IBI was decreased with age. BRSf was IBI-independent and better reflected the development of the baroreflex sensitivity.

  • Czech name

    Je možno detekovat vývoj citlivosti baroreflexu u člověka ve věku 11 až 20 let?

  • Czech description

    Cílem práce bylo ukázat vývoj citlivosti baroreflexu (BRS[ms/mmHg]/BRSf[mHz/mmHg]) u člověka ve věku 11 ? 20 let. U 415 zdravých osob byly po dobu 5 min. zaznamenávány tep po tepu hodnoty srdečních intervalů (SI), popř. srdeční frekvence, systolického adiastolického tlaku. BRS nekorelovalo s věkem, naopak BRSf s věkem významně klesalo (p<0.001). BRS korelovalo významně s SI (p<0.001), ale BRSf bylo na IBI nezávislé. Výsledky multiregresní analýzy: BRS=1,37-0,56*věk+0,02*SI (p<0.001 pro BRS vs.věk a pro BRS vs. SI); BRSf=34,74?0,97*věk-0.001*SI (p<0.001 pouze pro BRS vs. věk). Limity BRS: 5. percentil ? 3,9 ms/mmHg; 50. ? 9,1; 95. ? 18,7, a limity pro BRSf: 5. percentil ? 8,5 mHz/mmHg; 50. ? 16,4; 95. ? 33,6. Závěr: Na SI závislá BRS bylav jednotlivých věkových podskupinách nezměněná, ale po standardizaci BRS na IBI byl prokázán pokles s věkem. BRSf, která byla na SI nezávislá, lépe odrážela vývoj citlivosti baroreflexu.

Classification

  • Type

    Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Canadian Journal of Physiology and Pharmacology

  • ISSN

    1205-7541

  • e-ISSN

  • Volume of the periodical

    84

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    CA - CANADA

  • Number of pages

    9

  • Pages from-to

    1275-1283

  • UT code for WoS article

  • EID of the result in the Scopus database

Basic information

Result type

Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

Jx

CEP

ED - Physiology

Year of implementation

2006