Estimation Procedures for the False Discovery Rate: A Systematic Comparison for Microarray Data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00031811" target="_blank" >RIV/00216224:14110/06:00031811 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Estimation Procedures for the False Discovery Rate: A Systematic Comparison for Microarray Data
Original language description
The microarray technology developed in recent years allows for measuring expression levels of thousands of genes simultaneously. In most microarray experiments the measurements are taken under two experimental conditions. Statistical procedures to identify differentially expressed genes involve a serious multiple comparison problem as we have to carry out as many hypothesis testings as the number of candidate genes in the experiment. If we apply the usual type I error rate alpha in each testing, then the probability to reject any truly null hypothesis will greatly exceed the intended overall alpha level. We focus on the recent error control concept of the false discovery rate FDR for which an increasing number of competing estimates as well as algorithms is available. However, there is little comparative evidence.
Czech name
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Czech description
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Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
COMPSTAT 2006 - Proceedings in Computational Statistics
ISBN
3-7908-1708-2
ISSN
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e-ISSN
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Number of pages
12
Pages from-to
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Publisher name
Springer Verlag
Place of publication
Rome, Italy
Event location
Rome, Italy
Event date
Jan 1, 2006
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000242170000006

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