ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00019110" target="_blank" >RIV/00216224:14110/07:00019110 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
Original language description
Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. Aims To determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17.5 months, median age 57 years (39-67), DS stadium: stage I 7.1%, II 24.3%, III 68.6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78.5% including 13% CR, 27% VGPR and 38.5% PR. Me
Czech name
Asociácia chromozómových zmien a štantdardných prognostických faktorov u pacientov s mnohopočetným myelomom liečených autológnou transplantáciou
Czech description
Práce pojednává o význame chromozomových zmien a ich vztahu k štandardným prognostickým faktorom u pacientov s mnohopočetným myelomem léčených konvenčnou chemoterapiou a následnou autológnou transplantáciou.
Classification
Type
D - Article in proceedings
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR8183" target="_blank" >NR8183: Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Hematologica/The Hematology Journal
ISBN
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ISSN
0390-6078
e-ISSN
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Number of pages
1
Pages from-to
497-497
Publisher name
Ferrata-Storti Foundation
Place of publication
Pavia, Italy
Event location
Vienna, Austria
Event date
Jun 7, 2007
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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