CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00019111" target="_blank" >RIV/00216224:14110/07:00019111 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

Original language description

Introduction Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. The aim of this study was to determinethe correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Materials and Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17,5 months, median age 57 years (39-67), DS stadium: stage I 7,1%, II 24,3%, III 68,6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78,5% includ

Czech name

Vzťah medzi chromozómovými abnormalitami a štandardnými prognostickými faktormi u pacientov s mnohopočetným myelomom.

Czech description

Zaoberali sme sa koreláciou medzi chromozómovými aberáciami a štandardnými prognostickými faktormi u pacientov s mnohopočetným myelomom liečných konvenčnou chemoterapiou.

Type

D - Article in proceedings

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NR8183" target="_blank" >NR8183: Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Blood reviews

ISBN

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ISSN

0268-960X

e-ISSN

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Number of pages

1

Pages from-to

85-85

Publisher name

Churchill Livingstone

Place of publication

Edinburgh

Event location

Budapest, Hungary

Event date

Aug 29, 2007

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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