SNPs in adipokines - adiponectin and leptin - as risk factors for diabetic complications: evidence for a "double-hit" mechanism?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00019377" target="_blank" >RIV/00216224:14110/07:00019377 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
SNPs in adipokines - adiponectin and leptin - as risk factors for diabetic complications: evidence for a "double-hit" mechanism?
Original language description
Diabetic angiopathy is now recognized as an inflammatory process of the vessel wall. Type 2 diabetes (T2DM) is far the most common type frequently accompanied by obesity in affected subjects. Co-occurrence of both diseases is not just an epidemiologicalassociation but a likely consequence of common ethiopathogenesis. Adipokines too play multiple roles in inflammation ultimately activating, similarly to hyperglycemia itself, transcription factor NFkB with subsequent inflammatory changes in vascular tissue. Leptin (LEP) and adiponectin (APM1) are, apart of their role in energy homeostasis, examples of vascular pro- and anti-inflammatory mediators, respectively. Genetic variability in the APM1 and LEP genes could not only modulate the risk of obesity and/or T2DM but also influence susceptibility to the development of diabetic complications.
Czech name
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Czech description
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Project
<a href="/en/project/KJB501620601" target="_blank" >KJB501620601: Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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