Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00107509" target="_blank" >RIV/00216224:14110/19:00107509 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034" target="_blank" >http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034" target="_blank" >10.1590/1807-3107bor-2019.vol33.0034</a>

Result language

angličtina

Original language name

Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

Original language description

Specific variants in genes that encode adipokines and their mRNA and protein expression were previously studied in type 2 diabetes mellitus (T2DM) and obesity, and similar studies have been performed for chronic periodontitis (CP). The aim of this case-control study was to investigate the possible impacts of adiponectin (ADIPOQ), leptin (LEP) and its receptor (LEPR), and resistin (RETN) on the etiopathogenesis of CP. Examinations were performed on 118 non-periodontitis healthy subjects (healthy controls, HC), 205 healthy individuals with CP (H + CP) and 86 type 2 diabetes patients with CP (T2DM + CP). Variants within the ADIPOQ (rs2241766, rs1501299), LEP (rs13228377, rs2167270), LEP receptor (rs1805096), and RETN (rs1862513) genes were determined by qPCR. In addition, the plasma levels of ADIPOQ, LEP, and RETN were analysed by ELISA for 80 individuals. The genotype frequencies of the SNP ADIPOQ + 45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, p(corr)&gt;0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p&lt;0.01, p(corr)&gt;0.05). However, there were no significant differences in the plasma levels of ADIPOQ, LEP or RETN between the study groups (p &gt; 0.05). Plasma levels of the adipokines were also independent of the gene profiles (p &gt; 0.05). Adipokine plasma levels did not change in patients with H + CP/T2DM + CP compared to HC, but we did identify a specific polymorphism in the ADIPOQ gene that was associated with CP. Although the ADIPOQ + 45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

<a href="/en/project/GB14-37368G" target="_blank" >GB14-37368G: Centre of orofacial development and regeneration</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BRAZILIAN ORAL RESEARCH

ISSN

1807-3107

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

e034

Country of publishing house

BR - BRAZIL

Number of pages

12

Pages from-to

1-12

UT code for WoS article

000468342300001

EID of the result in the Scopus database

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