Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00021770" target="_blank" >RIV/00216224:14110/07:00021770 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata

Original language description

Aim: Polymorphisms in RXRs are very interesting from the point of view of possible association of their variability with psoriasis. Methods: The total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects havebeen enrolled in this study focused on three polymorphisms in RXRA and RXRB genes associations. Results: A marginally significant increase in AA allelic frequency of RXRA A(39526)AA polymorphism in plaque psoriatic men compared to healthy ones was proved. In women with psoriasis guttata, the higher risk for genotypes AA and TT in RXRB 3+ 140A/T polymorphism compared to healthy women was identified ( Pcorr=0.01). The genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with positive family history of psoriasis compared to the patients with negative family history of psoriasis (Pcorr=0.02). The A/A genotype is more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomia (P=0.02). In RXRB polym

Czech name

Tři polymorfismy v genu pro RXR receptor u pacientů s psoriasis en plaque a psoriasis guttata

Czech description

Individuální genové charakteristiky pacientů s psoriázou zlepšují možnosti farmakoterapie pomocí farmakogenomického přístupu. Studie hodnotí potenciál tří polymorfismů v receptoru RXR pro možný farmakogenomický zásah u pacientů s psoriasis vulgaris chronica a psoriasis guttata.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dermatology

ISSN

1018-8665

e-ISSN

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Volume of the periodical

02/2007

Issue of the periodical within the volume

214

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

118-124

UT code for WoS article

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EID of the result in the Scopus database

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