HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00035816" target="_blank" >RIV/00216224:14110/08:00035816 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens

Original language description

Both the human leucocyte antigen (HLA) BRB1 and the HLA BRB1 gene loci play a role in the development and progression of autoimmune diabetes mellitus (T1DM).Similarly, the insulin promoter variable number tandem repeats (INS-VNTR) polymorphism is also involved in the pathogenesis of diabetes mellitus (DM). We studied the association between each of these polymorphisms and DM diagnosed in patients older than age 35 years. Furthermore, we analysed possible interactions between HLA BRB1/DQB1 and INS-VNTR polymorphisms.

Czech name

HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens

Czech description

Both the human leucocyte antigen (HLA) BRB1 and the HLA BRB1 gene loci play a role in the development and progression of autoimmune diabetes mellitus (T1DM).Similarly, the insulin promoter variable number tandem repeats (INS-VNTR) polymorphism is also involved in the pathogenesis of diabetes mellitus (DM). We studied the association between each of these polymorphisms and DM diagnosed in patients older than age 35 years. Furthermore, we analysed possible interactions between HLA BRB1/DQB1 and INS-VNTR polymorphisms.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of immunogenetics

ISSN

1744-3121

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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