HLA alleles in autoimmune diabetes mellitus with onset after 35 year
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00063510" target="_blank" >RIV/00216224:14110/11:00063510 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
HLA alleles in autoimmune diabetes mellitus with onset after 35 year
Original language description
We summarize that in the Central Bohemian population of the Czech Republic, the INS ?23HphI A allele appears to be associated with a decrease in pancreatic beta cell secretory activity. HLA genotyping points to at least a partial difference in mechanism,which leads to T1DM and LADA development as well as a more diverse genetic predisposition in juvenile- and adult-onset diabetes. The simultaneous effect of HLA and INS-VNTR alleles/ genotypes predispose individuals to an increased risk of diabetes development.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů