Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F09%3A00029671" target="_blank" >RIV/00216224:14110/09:00029671 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
Original language description
The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ionic channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known toprolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models, mainly after its acute administration. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomollar concentration of haloperidol. Hearts from both untreated and chronicallyto haloperidol exposed animals were investigated.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA102%2F07%2F1473" target="_blank" >GA102/07/1473: Optical Methods for Registration of Heart Electrical Potentials and Calcium Concentration with Laser Stabilization</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Canadian Journal of Physiology and Pharmacology
ISSN
1205-7541
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
12
Country of publishing house
CA - CANADA
Number of pages
9
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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