Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F06%3APU62586" target="_blank" >RIV/00216305:26220/06:PU62586 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram

Original language description

Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol.

Czech name

Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram

Czech description

Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol.

Type

D - Article in proceedings

CEP classification

JD - Use of computers, robotics and its application

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Computers in Cardiology 2006

ISBN

0-7803-8894-1

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

1-4

Publisher name

IEEE

Place of publication

Valencia

Event location

Valencia

Event date

Sep 17, 2006

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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