ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00040848" target="_blank" >RIV/00216224:14110/10:00040848 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Original language description

We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated withthe development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity thanpatients with preserved LV function.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NS9880" target="_blank" >NS9880: Mnagment of care of patients with acute heart failure, their min-term prognosis and multivariate prognostic model.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Cardiovascular Disorders

ISSN

1471-2261

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

60

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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