The association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute heart Failure and Left ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary percutaneous Coronary Intervention
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001645" target="_blank" >RIV/65269705:_____/12:#0001645 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/12:00064899 RIV/00159816:_____/12:00060682
Result on the web
<a href="http://dx.doi.org/10.1089/gtmb.2012.0120" target="_blank" >http://dx.doi.org/10.1089/gtmb.2012.0120</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/gtmb.2012.0120" target="_blank" >10.1089/gtmb.2012.0120</a>
Alternative languages
Result language
angličtina
Original language name
The association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute heart Failure and Left ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary percutaneous Coronary Intervention
Original language description
Aims: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. Methods: In total, 556 patients with STEMI were evaluated. Levels ofTIMP-1 were measured at admission and 24?h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. Results: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genetic Testing and Molecular Biomarkers
ISSN
1945-0265
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1172-1178
UT code for WoS article
000309957500004
EID of the result in the Scopus database
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