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The association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute heart Failure and Left ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary percutaneous Coronary Intervention

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001645" target="_blank" >RIV/65269705:_____/12:#0001645 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/12:00064899 RIV/00159816:_____/12:00060682

  • Result on the web

    <a href="http://dx.doi.org/10.1089/gtmb.2012.0120" target="_blank" >http://dx.doi.org/10.1089/gtmb.2012.0120</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/gtmb.2012.0120" target="_blank" >10.1089/gtmb.2012.0120</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute heart Failure and Left ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary percutaneous Coronary Intervention

  • Original language description

    Aims: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. Methods: In total, 556 patients with STEMI were evaluated. Levels ofTIMP-1 were measured at admission and 24?h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. Results: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Genetic Testing and Molecular Biomarkers

  • ISSN

    1945-0265

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    1172-1178

  • UT code for WoS article

    000309957500004

  • EID of the result in the Scopus database