Pharmaceutical importance of zinc and metallothionein in cell signaling.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00040866" target="_blank" >RIV/00216224:14110/10:00040866 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/10:00002647

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Pharmaceutical importance of zinc and metallothionein in cell signaling.

Original language description

Zinc as an essential element plays the crucial role in many physiological, but also pathological processes - zinc controls cell proliferation, differentiation, and viability including the apoptosis. These facts are especially based on the structural roleof zinc ions in many proteins including the transcription factors. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transportersand low-molecular proteins metallothioneins (MTs) of the molecular weight between 6 and 10 kDa, which were firstly discovered in a horse kidneys as the cadmium binding protein. High affinity of metallothioneins to the zinc ions indicates their significant participation in the physiological, but also pathological processes, which are controlled by zinc. This paper summarizes the connection between metallothioneins and zinc and its significance on the molecular basis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/NS10200" target="_blank" >NS10200: Tumor markers, their determination and correlation with prostate carcinoma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chimica Oggi/Chemistry today

ISSN

0392-839X

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

6

Country of publishing house

IT - ITALY

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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