Metallothioneins in Prion- and Amyloid-Related Diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F16%3A43909567" target="_blank" >RIV/62156489:43210/16:43909567 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00090727 RIV/00216305:26620/16:PU120145

Result on the web

<a href="http://dx.doi.org/10.3233/JAD-150984" target="_blank" >http://dx.doi.org/10.3233/JAD-150984</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-150984" target="_blank" >10.3233/JAD-150984</a>

Result language

angličtina

Original language name

Metallothioneins in Prion- and Amyloid-Related Diseases

Original language description

Prion and other amyloid-forming diseases represent a group of neurodegenerative disorders that affect both animals and humans. The role of metal ions, especially copper and zinc is studied intensively in connection with these diseases. Their involvement in protein misfolding and aggregation and their role in creation of reactive oxygen species have been shown. Recent data also show that metal ions not only bind the proteins with high affinity, but also modify their biochemical properties, making them important players in prion-related diseases. In particular, the level of zinc ions is tightly regulated by several mechanisms, including transporter proteins and the low molecular mass thiol-rich metallothioneins. From four metallothionein isoforms, metallothionein-3, a unique brain-specific metalloprotein, plays a crucial role only in this regulation. This review critically evaluates the involvement of metallothioneins in prion- and amyloid-related diseases in connection with the relationship between metallothionein isoforms and metal ion regulation of their homeostasis.

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Alzheimer's Disease

ISSN

1387-2877

e-ISSN

—

Volume of the periodical

51

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

20

Pages from-to

637-656

UT code for WoS article

000374240200001

EID of the result in the Scopus database

2-s2.0-84963757777