Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00046962" target="_blank" >RIV/00216224:14110/10:00046962 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte

Original language description

An existing model of the rat ventricular myocyte was modified to reproduce the experimentally observed differential effects of the fast and slow exogenous Ca2+ buffers BAPTA and EGTA on inactivation of ICa and to investigate the possible cause. The results of the simulations suggest that the different potencies of EGTA and BAPTA on inactivation of ICa are due to their different rates of Ca2+ binding, and thus different intracellular gradients of bound and unbound buffer, causing different rates of diffusion of bound and unbound buffer out of and into the dyadic space. The consequent difference in suppression of the Ca2+ transient in the dyadic space caused different rates of Ca2+ - induced inactivation of ICa in the presence of the two buffers.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analysis of Biomedical Signals and Images

ISSN

1211-412X

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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