Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F14%3A00430874" target="_blank" >RIV/61388998:_____/14:00430874 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/14:00080146
Result on the web
<a href="http://dx.doi.org/10.1155/2014/920208" target="_blank" >http://dx.doi.org/10.1155/2014/920208</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/920208" target="_blank" >10.1155/2014/920208</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study
Original language description
We have used a previously published computer model of the rat cardiac ventricular myocyte to investigate the effect of changing the distribution of Ca efflux pathways (SERCA, Na/Ca exchange, and sarcolemmal Ca ATPase) between the dyad and bulk cytoplasmand the effect of adding exogenous Ca buffers (BAPTA or EGTA), which are used experimentally to differentially buffer Ca in the dyad and bulk cytoplasm, on cellular Ca cycling. Increasing the dyadic fraction of a particular Ca efflux pathway increases the amount of Ca removed by that pathway, with corresponding changes in Ca efflux from the bulk cytoplasm. The magnitude of these effects varies with the proportion of the total Ca removed from the cytoplasm by that pathway. Differences in the response toEGTA and BAPTA, including changes in Ca-dependent inactivation of the L-type Ca current, resulted from the buffers acting as slow and fast ?shuttles, respectively, removing Ca from the dyadic space. The data suggest that complex changes i
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14301" target="_blank" >NT14301: Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents: a link to atrial fibrillation related to alcohol consumption?</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
2014
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
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UT code for WoS article
000337478800001
EID of the result in the Scopus database
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