Laboratory for Cell Biology of Human Pathogenic Yeasts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00048675" target="_blank" >RIV/00216224:14110/10:00048675 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Laboratory for Cell Biology of Human Pathogenic Yeasts
Original language description
Our recent research identified cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis.The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. The cytoskeleton was investigated as a potential target of inhibition using microtubule and actin inhibitors. All microtubule inhibitors were effective, while clinical ones had only transient effect and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth and conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors(Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study brought new findings of the basic research on the cytoskeleton as a new target for inhibition of yeast human pathogens, which may show the way to a new antifungal strategy.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA310%2F06%2F0605" target="_blank" >GA310/06/0605: Human pathogenic fungi : the cytoskeleton as a potential target of inhibition of morphogenesis.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Fifty Years of Czechoslovak Yeast Research, Period 2000-2009.
ISBN
978-80-89257-20-1
Number of pages of the result
3
Pages from-to
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Number of pages of the book
110
Publisher name
Commission on Yeasts, Czechoslovak Microbiological Society
Place of publication
Bratislava, Slovenská republika
UT code for WoS chapter
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