YEAST PATHOGENS: THE CYTOSKELETON AND THE CELL WALL AS TARGETS FOR ANTIFUNGALS-INVITED LECTURE

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00048676" target="_blank" >RIV/00216224:14110/10:00048676 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
YEAST PATHOGENS: THE CYTOSKELETON AND THE CELL WALL AS TARGETS FOR ANTIFUNGALS-INVITED LECTURE
Original language description
We identified the cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis. The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. We investigated the cytoskeleton as a potential target for inhibition of morphogenesis using microtubule and actin inhibitors. All microtubule inhibitors were effective, but clinical ones only transiently and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth, conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors (Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study provided new results of the basic research on the cytoskeleton as a new potent target for inhibition of yeast pathogens that may show the way to a new antifungal strategy.
Czech name
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Czech description
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Project
<a href="/en/project/GA310%2F06%2F0605" target="_blank" >GA310/06/0605: Human pathogenic fungi : the cytoskeleton as a potential target of inhibition of morphogenesis.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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