Association of aneuploidy category with centrosome amplification in multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00050008" target="_blank" >RIV/00216224:14110/11:00050008 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/11:#0001325
Result on the web
<a href="http://dx.doi.org/10.3109/10428194.2011.587561" target="_blank" >http://dx.doi.org/10.3109/10428194.2011.587561</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10428194.2011.587561" target="_blank" >10.3109/10428194.2011.587561</a>
Alternative languages
Result language
angličtina
Original language name
Association of aneuploidy category with centrosome amplification in multiple myeloma
Original language description
Multiple myeloma is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells (PCs) within the bone marrow. Although PCs are recognized as fully malignant cells, the exact developmental stage at which malignant transformation occurs is still unknown. Since centrosome abnormalities constitute one of the most important mechanisms implicated in chromosomal instability in cancer, the aim of this study was to investigate a possible association of centrosome amplification in populations of B-cell lineage with specific chromosome aberrations and aneuploidy categories occurring in MM. For this purpose, a total of 140 patients with MM were included in the study. In our study, we showed a correlation between centrosome amplification in B cells and hyperdiploidy in plasma cells. This raises the suspicion of a possible impact of abnormal B cells in myeloma cell development.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia & Lymphoma
ISSN
1042-8194
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
2020-2022
UT code for WoS article
000295176800030
EID of the result in the Scopus database
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