Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00050101" target="_blank" >RIV/00216224:14110/11:00050101 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/11:#0001222
Result on the web
<a href="http://dx.doi.org/10.1016/j.leukres.2011.03.001" target="_blank" >http://dx.doi.org/10.1016/j.leukres.2011.03.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.leukres.2011.03.001" target="_blank" >10.1016/j.leukres.2011.03.001</a>

Result language
angličtina
Original language name
Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients
Original language description
Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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