Effects of Voltage-Sensitive Dye di-4-ANEPPS on Isolated Rat Heart Electrogram

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00050213" target="_blank" >RIV/00216224:14110/11:00050213 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of Voltage-Sensitive Dye di-4-ANEPPS on Isolated Rat Heart Electrogram

Original language description

Although the classical suction microelectrodes are still considered golden standard for recording of monophasic action potentials, there are various new methods enabling to record electrical changes from small area on the heart surface. One of them is recording of cardiac electrical activity using voltage-sensitive dyes (VSDs) by optical method. VSDs exhibit large fluorescence and/or absorption changes that vary with changes of the membrane potential. Staining of the heart with the dye should not resultin pharmacological or toxic effects to the preparation. Data about response of the heart to staining with VSD are scarce. In order to determine this response in classical biomodel in basic cardiology, we followed arrythmia-preceding parameters in isolated rat heart electrogram during staining with VSD di-4-ANEPPS and washout periods.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/GA102%2F07%2F1473" target="_blank" >GA102/07/1473: Optical Methods for Registration of Heart Electrical Potentials and Calcium Concentration with Laser Stabilization</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Computing in Cardiology

ISSN

0276-6574

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

721-724

UT code for WoS article

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EID of the result in the Scopus database

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