Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00054780" target="_blank" >RIV/00216224:14110/11:00054780 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3324/haematol.2011.041434" target="_blank" >http://dx.doi.org/10.3324/haematol.2011.041434</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2011.041434" target="_blank" >10.3324/haematol.2011.041434</a>

Result language

angličtina

Original language name

Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients

Original language description

Bortezomib induced peripheral neuropathy is a dose-limiting side effect and a major concern in the treatment of multiple myeloma. To identify genetic risk factors associated with the development of this side effect in bortezomib treated multiple myelomapatients, a pharmacogenetic association study was performed using a discovery set (IFM 2005-01; n=238) and a validation set (HOVON65/GMMG-HD4 and a Czech dataset; n=231). After multiplicity correction, none of the 2,149 single nucleotide polymorphisms tested revealed any significant association with bortezomib induced peripheral neuropathy. However, 56 single nucleotide polymorphisms demonstrated an association with bortezomib induced peripheral neuropathy with pointwise, uncorrected significance. Pathway analysis of these polymorphisms demonstrated involvement of neurological disease (FDR &lt;20%). Also a clear enrichment of major bortezomib metabolizing genes was found.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/LC06027" target="_blank" >LC06027: University Research Centre - Czech Myeloma Group</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica/the hematology journal

ISSN

0390-6078

e-ISSN

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Volume of the periodical

96

Issue of the periodical within the volume

11

Country of publishing house

IT - ITALY

Number of pages

5

Pages from-to

1728-1732

UT code for WoS article

000297243800027

EID of the result in the Scopus database

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