Genetic factors undertying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patiens
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001256" target="_blank" >RIV/65269705:_____/11:#0001256 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3324/haematol.2011.041434" target="_blank" >http://dx.doi.org/10.3324/haematol.2011.041434</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2011.041434" target="_blank" >10.3324/haematol.2011.041434</a>
Alternative languages
Result language
angličtina
Original language name
Genetic factors undertying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patiens
Original language description
Bortezomib induced peripheral neuropathy is a dose-limiting side effect and a major concern in the treatment of multiple myeloma. To identify genetic risk factors associated with the development of this side effect in bortezomib treated multiple myelomapatients, a pharmacogenetic association study was performed using a discovery set (IFM 2005-01; n=238) and a validation set (HOVON65/GMMG-HD4 and a Czech dataset; n=231). After multiplicity correction, none of the 2,149 single nucleotide polymorphisms tested revealed any significant association with bortezomib induced peripheral neuropathy. However, 56 single nucleotide polymorphisms demonstrated an association with bortezomib induced peripheral neuropathy with pointwise, uncorrected significance. Pathway analysis of these polymorphisms demonstrated involvement of neurological disease (FDR <20%). Also a clear enrichment of major bortezomib metabolizing genes was found. Univariate evaluation of these 56 polymorphisms in the validation se
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC06027" target="_blank" >LC06027: University Research Centre - Czech Myeloma Group</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
11
Country of publishing house
IT - ITALY
Number of pages
5
Pages from-to
1728-1732
UT code for WoS article
000297243800027
EID of the result in the Scopus database
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