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Identification of prognostic factors for plerixafor-based hematopoietic stem cell mobilization

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055088" target="_blank" >RIV/00216224:14110/11:00055088 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/11:#0001356

  • Result on the web

    <a href="http://dx.doi.org/10.1002/ajh.22038" target="_blank" >http://dx.doi.org/10.1002/ajh.22038</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ajh.22038" target="_blank" >10.1002/ajh.22038</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Identification of prognostic factors for plerixafor-based hematopoietic stem cell mobilization

  • Original language description

    The introduction of plerixafor has enabled successful collection of stem cells in the majority of patients with lymphoma or myeloma in whom previous attempts at mobilization have failed. However, a proportion of patients have been shown to be resistant to this mobilization regimen. To identify the factors that impair stem cell mobilization and collection with plerixafor, we reviewed the data for 197 patients who had undergone mobilization with plerixafor and granulocyte-colony stimulating factor in Central Europe. Predictors of mobilization failure were evaluated using logistic regression analysis. Among the 197 patients mobilized, the target of more than 2.0 x 10(6) CD34+ cells/kg was collected from 133 (67.5%). Our analysis revealed that previous treatment with lenalidomide, bortezomib, melphalan, radiotherapy, or autologous stem cell transplantation and regimen of plerixafor use in combination with chemotherapy had no significant effect on the efficiency of collection.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    American Journal of Hematology

  • ISSN

    0361-8609

  • e-ISSN

  • Volume of the periodical

    86

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    4

  • Pages from-to

    550-553

  • UT code for WoS article

    000291938000005

  • EID of the result in the Scopus database