Identification of prognostic factors for plerixafor-based hematopoietic stem cell mobilization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055088" target="_blank" >RIV/00216224:14110/11:00055088 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/11:#0001356
Result on the web
<a href="http://dx.doi.org/10.1002/ajh.22038" target="_blank" >http://dx.doi.org/10.1002/ajh.22038</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.22038" target="_blank" >10.1002/ajh.22038</a>
Alternative languages
Result language
angličtina
Original language name
Identification of prognostic factors for plerixafor-based hematopoietic stem cell mobilization
Original language description
The introduction of plerixafor has enabled successful collection of stem cells in the majority of patients with lymphoma or myeloma in whom previous attempts at mobilization have failed. However, a proportion of patients have been shown to be resistant to this mobilization regimen. To identify the factors that impair stem cell mobilization and collection with plerixafor, we reviewed the data for 197 patients who had undergone mobilization with plerixafor and granulocyte-colony stimulating factor in Central Europe. Predictors of mobilization failure were evaluated using logistic regression analysis. Among the 197 patients mobilized, the target of more than 2.0 x 10(6) CD34+ cells/kg was collected from 133 (67.5%). Our analysis revealed that previous treatment with lenalidomide, bortezomib, melphalan, radiotherapy, or autologous stem cell transplantation and regimen of plerixafor use in combination with chemotherapy had no significant effect on the efficiency of collection.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Hematology
ISSN
0361-8609
e-ISSN
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Volume of the periodical
86
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
550-553
UT code for WoS article
000291938000005
EID of the result in the Scopus database
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