Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055096" target="_blank" >RIV/00216224:14110/11:00055096 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/11:#0001507 RIV/00209805:_____/11:#0000182
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2011_05_377" target="_blank" >http://dx.doi.org/10.4149/neo_2011_05_377</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2011_05_377" target="_blank" >10.4149/neo_2011_05_377</a>
Alternative languages
Result language
angličtina
Original language name
Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
Original language description
Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels ofPAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
5
Country of publishing house
SK - SLOVAKIA
Number of pages
9
Pages from-to
377-385
UT code for WoS article
000295309700003
EID of the result in the Scopus database
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