Clinical Relevance of uPA, uPAR, PAI 1, PAI 2, Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patiens
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001449" target="_blank" >RIV/65269705:_____/11:#0001449 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5754/hge10232" target="_blank" >http://dx.doi.org/10.5754/hge10232</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5754/hge10232" target="_blank" >10.5754/hge10232</a>
Alternative languages
Result language
angličtina
Original language name
Clinical Relevance of uPA, uPAR, PAI 1, PAI 2, Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patiens
Original language description
BACKGROUND/AIMS: Urokinase (uPA) is a serine protease, which together with uPAR, tPA, PAI 1 and PAI 2 forms the plasminogen activator system, a component of metastatic cascade contributing to the invasive growth and angiogenesis of malignant tumours. METHODOLOGY: Both preceding therapy and after 6-8 weeks of the treatment, plasma PAI 1 levels (photometric microplate method on the ELISA) and uPA, uPAR, PAI 1 and PAI 2 tissue expression (immunohistochemical reaction) were analysed from 80 colorectal carcinoma patients. RESULTS: Analysis showed higher pre-treatment plasma levels of PAI 1 in patients with advanced tumours, which decreased after surgery or the start of therapy (p=0.004); Patients with higher plasma level PAI 1 before (0.013) and after therapy (0.004) had significantly shorter survival. There was a higher expression of uPA (p<0.001), uPAR (p<0.001), PAI 1 (p=0.042) and PAI 2 (p<0.001) in advanced colorectal carcinoma. A relationship between PAI 2 (p=0.010) and uPAR (p=0.019)
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hepato-Gastroenterology
ISSN
0172-6390
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
112
Country of publishing house
GR - GREECE
Number of pages
8
Pages from-to
1918-1925
UT code for WoS article
000300532700015
EID of the result in the Scopus database
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