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Clinical Relevance of uPA, uPAR, PAI 1, PAI 2, Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patiens

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001449" target="_blank" >RIV/65269705:_____/11:#0001449 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.5754/hge10232" target="_blank" >http://dx.doi.org/10.5754/hge10232</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5754/hge10232" target="_blank" >10.5754/hge10232</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Clinical Relevance of uPA, uPAR, PAI 1, PAI 2, Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patiens

  • Original language description

    BACKGROUND/AIMS: Urokinase (uPA) is a serine protease, which together with uPAR, tPA, PAI 1 and PAI 2 forms the plasminogen activator system, a component of metastatic cascade contributing to the invasive growth and angiogenesis of malignant tumours. METHODOLOGY: Both preceding therapy and after 6-8 weeks of the treatment, plasma PAI 1 levels (photometric microplate method on the ELISA) and uPA, uPAR, PAI 1 and PAI 2 tissue expression (immunohistochemical reaction) were analysed from 80 colorectal carcinoma patients. RESULTS: Analysis showed higher pre-treatment plasma levels of PAI 1 in patients with advanced tumours, which decreased after surgery or the start of therapy (p=0.004); Patients with higher plasma level PAI 1 before (0.013) and after therapy (0.004) had significantly shorter survival. There was a higher expression of uPA (p<0.001), uPAR (p<0.001), PAI 1 (p=0.042) and PAI 2 (p<0.001) in advanced colorectal carcinoma. A relationship between PAI 2 (p=0.010) and uPAR (p=0.019)

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Hepato-Gastroenterology

  • ISSN

    0172-6390

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    112

  • Country of publishing house

    GR - GREECE

  • Number of pages

    8

  • Pages from-to

    1918-1925

  • UT code for WoS article

    000300532700015

  • EID of the result in the Scopus database