Minimal residual disease in peripheral blood at day 15 identifies a subgroup of childhood B-cell presursor acute lymphoblastic leukemia with superior prognosis.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055521" target="_blank" >RIV/00216224:14110/11:00055521 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3324/haematol.2011.042937" target="_blank" >http://dx.doi.org/10.3324/haematol.2011.042937</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2011.042937" target="_blank" >10.3324/haematol.2011.042937</a>
Alternative languages
Result language
angličtina
Original language name
Minimal residual disease in peripheral blood at day 15 identifies a subgroup of childhood B-cell presursor acute lymphoblastic leukemia with superior prognosis.
Original language description
Most minimal residual disease-directed treatment interventions in current treatment protocols for acute lymphoblastic leukemia are based on bone marrow testing, which is a consequence of previous studies showing the superiority of bone marrow over peripheral blood as an investigational material. Those studies typically did not explore the prognostic impact of peripheral blood involvement and lacked samples from very early time points of induction. Design and Methods In this study, we employed real-timequantitative polymerase chain reaction analysis to examine minimal residual disease in 398 pairs of blood and bone marrow follow-up samples taken from 95 children with B-cell precursor acute lymphoblastic leukemia treated with the ALL IC-BFM 2002 protocol. Results We confirmed the previously published poor correlation between minimal residual disease in blood and marrow at early treatment time points, with levels in bone marrow being higher than in blood in most samples (median 7.9-fold,
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hematologica - The Hematology Journal
ISSN
0390-6078
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
12
Country of publishing house
IT - ITALY
Number of pages
7
Pages from-to
1815-1821
UT code for WoS article
000298544400015
EID of the result in the Scopus database
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