Rhabdomyosarcoma: molecular analysis of Igf2, MyoD1 and Myogenin expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055927" target="_blank" >RIV/00216224:14110/11:00055927 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7114 RIV/65269705:_____/11:#0001595 RIV/00064203:_____/11:7114
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2011_05_415" target="_blank" >http://dx.doi.org/10.4149/neo_2011_05_415</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2011_05_415" target="_blank" >10.4149/neo_2011_05_415</a>
Alternative languages
Result language
angličtina
Original language name
Rhabdomyosarcoma: molecular analysis of Igf2, MyoD1 and Myogenin expression
Original language description
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. There are two major histopathological types of RMS - embryonal (eRMS) and alveolar (aRMS). A molecular study of Igf2, MyoD1 and Myogenin was performed to determine the expression profiles and to assess the possible utility of these genes as potential treatment targets. Patients with RMS showed up to 100-fold increase of Igf2 transcription in comparison with normal skeletal muscle. Our data suggest that overexpression of Igf2 occurs inRMS of both histological subtypes. No correlation between the results of Igf2 mRNA expression and LOH at the 11p15 region (p=0.12) was observed, but there was a trend of a higher expression of Igf2 mRNA in RMS samples with LOH. We observed a high levelof MyoD1 mRNA in both aRMS and eRMS, and we detected a similar level of MyoD1 mRNA in RMS and normal skeletal muscles. There was a correlation between the results of MyoD1 mRNA expression and LOH at the 11p15 region.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA304%2F07%2F0532" target="_blank" >GA304/07/0532: Minimal disseminated disease study in rhabdomyosarcoma using real-time quantitative reverse transcriptase polymerase chain reaction</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
5
Country of publishing house
SK - SLOVAKIA
Number of pages
9
Pages from-to
415-423
UT code for WoS article
000295309700008
EID of the result in the Scopus database
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