The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00085064" target="_blank" >RIV/00216224:14110/15:00085064 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/15:00455816 RIV/65269705:_____/15:00063561

Result on the web

<a href="http://dx.doi.org/10.1038/srep15090" target="_blank" >http://dx.doi.org/10.1038/srep15090</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/srep15090" target="_blank" >10.1038/srep15090</a>

Result language

angličtina

Original language name

The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin

Original language description

The transcription factor c-Myb is required for modulation of progenitor cells in several tissues, including skeletal muscle and its upregulation is observed in many human malignancies. Rhabdomyosarcomas (RMS) are a heterogeneous group of mesodermal tumors with features of developing skeletal muscle. Several miRNAs are downregulated in RMS, including miR-150, a negative regulator of c-Myb expression. Using the C2C12 myoblast cell line, a cellular model of skeletal muscle differentiation, we showed that miR-150 controls c-Myb expression mainly at the level of translation. We hypothesized that a similar mechanism of c-Myb regulation operates in RMS tumors. We examined expression of c-Myb by immunohistochemistry and revealed c-Myb positivity in alveolar and embryonal tumors, the two most common subgroups of RMS. Furthermore, we showed direct correlation between c-Myb production and myogenin expression. Interestingly, high myogenin levels indicate poor prognosis in RMS patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

15090

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

1-10

UT code for WoS article

000362718600003

EID of the result in the Scopus database

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