Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00057824" target="_blank" >RIV/00216224:14110/12:00057824 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/12:#0001882

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0049446" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0049446</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0049446" target="_blank" >10.1371/journal.pone.0049446</a>

Result language

angličtina

Original language name

Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment

Original language description

Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and enhance immune dysfunction. In this study, we aimed to prove the presence of functionally suppressive Treg cells expressing CD8 phenotype (CD8 Treg cells) in MM. To the best of our knowledge, this has not been reported previously in MM. METHODS: We analyzed CD8 Treg cells and their transcription factor FoxP3 from 64 newly diagnosed MM patients using flow cytometry and real time-polymerase chain reaction (RT-PCR). RNA profile of cytokines in CD8 Treg cells was also assessed using RT-PCR. CD8 Treg cells from 5 MM patients and 5 healthy donors were functionally evaluated using proliferation assays. RESULTS: CD8 Treg cells (CD8+CD25hi+) were significantly elevated in MM patients (P&lt;0.0001), and their transcription factor FoxP3 expression was also higher

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Public Library of Science one

ISSN

1932-6203

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

"e49446"

UT code for WoS article

000311234600041

EID of the result in the Scopus database

—